NEUROLOGICAL MOUSE MUTANTS AND THE GENES OF MYELIN

被引：87

作者：

NAVE, KA

机构：

[1] Zentrum Für Molekulare Biologie, Universität Heidelberg, Heidelberg

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 1994年 / 38卷 / 06期

关键词：

MOUSE MUTANTS; MYELIN GENES; MYELIN PROTEIN FUNCTION;

D O I：

10.1002/jnr.490380602

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The prospect to create mouse mutants of virtually any cloned gene has renewed interest in the genetic analysis of mammalian brain development. A diverse group of spontaneous and engineered mouse mutants, characterized by a defect of myelin formation, has been intensively studied from the morphological to the molecular level. In this system, genetics has been successfully applied to analyze a corresponding set of membrane proteins which help to elaborate a defined structural entity, compact myelin. Shiverer, jimpy, Trembler, and protein zero (PO)-deficient mice demonstrate the overall function of myelination and have become models for human neurological diseases. They also illustrate some of the problems encountered in defining protein functions from complex mutant phenotypes. (C) 1994 Wiley-Liss, Inc.

引用

页码：607 / 612

页数：6

共 51 条

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