POTENT GLYCOSIDASE INHIBITORS, N-PHENYL CYCLIC ISOUREA DERIVATIVES OF 5-AMINO-1-C-(HYDROXYMETHYL)-CYCLOPENTANE-1,2,3,4-TETRAOL AND 5-AMINO-CYCLOPENTANE-1,2,3,4-TETRAOL

被引：14

作者：

UCHIDA, C ^{[1
]}

KIMURA, H ^{[1
]}

OGAWA, S ^{[1
]}

机构：

[1] KEIO UNIV,FAC SCI & TECHNOL,DEPT APPL CHEM,KOHOKU KU,YOKOHAMA,KANAGAWA 223,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 22期

关键词：

D O I：

10.1016/S0960-894X(01)80688-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Nine N-phenyl cyclic isourea derivatives of 5-aminocyclopentane-polyols were prepared conventionally, and assayed for enzyme-inhibitory activity against five sugar hydrolases. Two derivatives derived from 1L-(1,2,4,5/3)-5-amino-1-C-(hydroxymethyl)cyclopentane-1,2,3,4-tetraol, and two from 1D-(1,2,3,5/4)- and DL-(1,4,5/2,3)-5-aminocyclopentane-1,2,3,4-tetraols have been shown to possess strong potency against alpha-glucosidase and beta-galactosidase, respectively.

引用

页码：2643 / 2648

页数：6

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