7-OH-DPAT PRODUCES PLACE CONDITIONING IN RATS

被引：23

作者：

MALLET, PE ^{[1
]}

BENINGER, RJ ^{[1
]}

机构：

[1] QUEENS UNIV,DEPT PSYCHOL,KINGSTON K7L 3N6,ON,CANADA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 261卷 / 03期

基金：

加拿大自然科学与工程研究理事会;

关键词：

7-OH-DPAT ((+/-)-2-DIPROPYLAMINO-7-HYDROXY-1,2,3,4-TETRAHYDRONAPHTHALENE HYDROBROMIDE); PLACE CONDITIONING; DOPAMINE D-3 RECEPTOR;

D O I：

10.1016/0014-2999(94)90127-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The rewarding properties of the putative dopamine D-3 receptor-selective agonist, 7-OH-DPAT((+/-)-2-dipropylamino-7-hy droxy-1,2,3,4-tetrahydronaphthalene hydrobromide), were investigated using a place conditioning paradigm consisting of three phases: preconditioning (three undrugged exposures to an apparatus consisting of two visually distinct compartments); conditioning (four pairings of one compartment with drug); and test (one undrugged exposure to the same apparatus). Rats received either saline, amphetamine (2.0 mg/kg), or 7-OH-DPAT (0.5, 2.0 or 5.0 mg/kg) during conditioning. Amphetamine and 7-OH-DPAT produced a place preference.

引用

页码：R5 / R6

页数：2

共 6 条

[1]

BENINGER RJ, 1993, D1 D2 DOPAMINE RECEP, P115

[2] MODULATION OF COCAINE SELF-ADMINISTRATION IN THE RAT THROUGH D-3 DOPAMINE-RECEPTORS [J].