EFFECTS OF AGING ON MICROGLIA IN THE NORMAL RAT-BRAIN - IMMUNOHISTOCHEMICAL OBSERVATIONS

被引：145

作者：

OGURA, K ^{[1
]}

OGAWA, M ^{[1
]}

YOSHIDA, M ^{[1
]}

机构：

[1] JICHI MED SCH,DEPT NEUROL,MINAMI KAWACHI,TOCHIGI 32904,JAPAN

来源：

NEUROREPORT | 1994年 / 5卷 / 10期

关键词：

MACROPHAGE; MICROGLIA; RAT; BRAIN; AGING;

D O I：

10.1097/00001756-199406020-00016

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE numbers of ramified microglia stained by mouse monoclonal antibodies (OX-6 and X-42) in various regions of the brain were compared in the young (8 weeks) and aged (12 months) rats. OX-6-positive microglia increased in number with ageing, but OX-42-positive microglia did not. In both young and aged rats, the number of OX-6-positive microglia in white matter was higher than that in grey matter, but the number of OX-42-positive microglia in white matter was the same as that in grey matter. OX-42 stains microglia in both activated and resting states, whereas OX-6 stains mainly microglia in the activated state. Our findings suggest that microglia become activated with age-related changes, especially in white matter.

引用

页码：1224 / 1226

页数：3

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