EFFECT OF D-LIMONENE ON THE TRANSDERMAL PERMEATION OF NIFEDIPINE AND DOMPERIDONE

The aim of this research is to study the profile of transdermal permeation of nifedipine and domperidone. Permeation studies were carried out using the skin of hairless rat and human skin as a membrane mounted in a permeation system in vitro. The influence of the type of skin used and the presence of d-limonene on the transdermal penetration of these drugs were studied. The drugs studied permeate approx. 3 times faster through rat skin than through human skin. The type of skin has no influence on the lag time. d-limonene increases the values of the permeability constant (K-p), flux (J) and lag time (T-l) for both drugs, but not the lag time for domperidone when human skin is used. The effect of the enhancer on the enhancement index (EI) of domperidone varies with the type of skin used (EI = 15.7 (rat skin) and EI = 7.7 (human skin)). When human skin is used, although penetration is increased by d-limonene, the concentration Values predicted at steady state are below therapeutic levels for both studied drugs.