HALOGEN SUBSTITUTED DERIVATIVES OF ACETYLCHOLINE AS INHIBITORS OF CHOLINE ACETYLTRANSFERASE

被引：29

作者：

MORRIS, D

GREWAAL, DS

机构：

[1] Department of Physiology and Biochemistry, University of Southampton, Southampton

来源：

LIFE SCIENCES PART 1 PHYSIOLOGY AND PHARMACOLOGY AND PART 2 BIOCHEMISTRY GENERAL AND MOLECULAR BIOLOGY | 1969年 / 8卷 / 10P2期

关键词：

D O I：

10.1016/0024-3205(69)90249-5

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The effect of chloro-, bromo- and iodoacetylcholine on ACh synthesis by human placental choline acetyltransferase has been investigated. All three compounds are potent inhibitors, chloroacetylcholine giving virtually complete inhibition at a concentration of 62.5 × 10-6 M. The inhibition is reversible and uncompetitive with respect to both choline and acetyl-CoA. A new radiochemical assay for the enzyme is outlined. © 1969.

引用

页码：511 / &

共 21 条

[1] CHOLINE ACETYLASE SPECIFICITY IN RELATION TO BIOLOGICAL FUNCTION [J].