IDENTIFICATION OF SOME URINARY CONJUGATED METABOLITES OF 17 BETA ESTRADIOL-6,7-3H-17-GLUCOSIDURONATE IN HUMAN FEMALE

被引：18

作者：

HOBKIRK, R

NILSEN, M

机构：

[1] University Medical Clinic, The Montreal General Hospital, Montreal, Que.

[2] Dept. of Experimental Medicine, McGill University, Montreal, Que.

来源：

STEROIDS | 1969年 / 14卷 / 05期

关键词：

D O I：

10.1016/S0039-128X(69)80046-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Following intravenous injection of 17β-estradiol-6,7-3H-17-glucosiduronate into a normal human female the urinary conjugated forms of labelled estrone and 17β-estradiol were identified by DEAE-Sephadex and Celite partition chromatography; comparison with certain authentic 14C-labelled conjugates; enzyme hydrolysis; crystallization with carrier steroids, including derivative formation. The main compounds identified were estrone-3-glucosiduronate, 17β-estradiol-17-glucosiduronate and 17β-estradiol-3-glucosiduronate in the approximate proportions of 5.6:3.7:1. Some evidence was also obtained for the presence of very small amounts of estrone-3-sulfate and 17β-estradiol-3-sulfate-17-glucosiduronate. © 1968 Holden-Day, Inc.

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页码：533 / +

页数：1

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