GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENT RED CELLS - RESISTANCE TO INFECTION BY MALARIAL PARASITES

被引:200
作者
LUZZATTO, L
USANGA, EA
REDDY, S
机构
[1] Sub-Department of Haematology, University College Hospital, Ibadan
关键词
D O I
10.1126/science.164.3881.839
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Erythrocyte mosaicism occurs in females heterozygous for glucose-6-phosphate dehydrogenase deficiency. In blood from female children with acute Plasmodium falciparum malaria the parasite rate was 2 to 80 times higher in normal than in deficient erythrocytes. This may be the mechanism whereby the gene for glucose-6-phosphate dehydrogenase deficiency confers selective advantage, against malaria to heterozygous females, and thus may have attained the polymorphic frequency occurring in populations living in areas with endemic malaria.
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页码:839 / &
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