CENTRAL EXCITATORY SEROTONERGIC OR SEROTONERGIC-LIKE SYNAPSE ON THE PATHWAY TO HEAT-PRODUCTION IN THE SHEEP

被引：12

作者：

BLIGH, J ^{[1
]}

SILVER, A ^{[1
]}

SMITH, CA ^{[1
]}

机构：

[1] ARC,INST ANIM PHYSIOL,CAMBRIDGE CB2 4AT,ENGLAND

来源：

JOURNAL OF THERMAL BIOLOGY | 1979年 / 4卷 / 04期

关键词：

5-hydroxytryptamine; Heat loss; heat production; hypothalamus; lysergic acid diethylamine; methysergide; norfenfluramine; sheep; thermoregulation;

D O I：

10.1016/0306-4565(79)90012-3

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

1. 1.|Intraventricular injections of serotonergic agonists and receptor blockers were given to sheep to determine whether the central nervous pathway mediating the drive to heat production involves serotonergic synapses. 2. 2.|At 15°C ambient temperature (Ta), 5-hydroxytryptamine (5-HT) at all doses tested, and norfenfluramine (NF) in low doses increased heat loss and decreased rectal temperature (Tre); lysergic acid diethylamide (LSD-25) and methysergide prevented these effects. 3. 3.|AT 0°C Ta, 5-HT, even in high doses failed to increase heat production but NF increased heat production and Tre. 4. 4.|The results suggest the effects of NF and LSD-25 on heat production may be related to synapses activated by an indoleamine other than 5-HT. © 1979.

引用

页码：259 / 268

页数：10

共 19 条

[1] LYSERGIC-ACID DIETHYLAMIDE AND SEROTONIN - DIRECT ACTION ON SEROTONIN-CONTAINING NEURONS IN RAT-BRAIN [J].