DIFFERENTIAL EFFECTS OF CHLOROQUINE AND OF SEVERAL OTHER AMPHIPHILIC CATIONIC DRUGS UPON RAT CHOROID-PLEXUS

被引：21

作者：

FRISCH, W ^{[1
]}

LULLMANNRAUCH, R ^{[1
]}

机构：

[1] UNIV KIEL,DEPT ANAT,D-2300 KIEL 1,FED REP GER

来源：

ACTA NEUROPATHOLOGICA | 1979年 / 46卷 / 03期

关键词：

Chloroquine; Chlorphentermine; Choroid plexus; Lipidosis; Rat;

D O I：

10.1007/BF00690845

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Several cationic amphiphilic drugs, each of which is known to induce generalized lipidosis in rats, were compared with respect to their cytological effects on rat choroid plexus epithelium. Chloroquine induced large cytoplasmic vacuoles, whereas the other drugs (quinacrine, 4,4′-diethylaminoethoxyhexestrol, chlorphentermine, iprindole, 1-chloro-amitriptyline, clomipramine) caused formation of lamellated or crystalloid inclusions as usually seen in drug-induced lipidosis. The ultrastructure of the chloroquine-induced vacuoles suggested storage of water-soluble materials (polar lipids and/or non-lipid materials) in addition to non-water-soluble polar lipids. © 1979 Springer-Verlag.

引用

页码：203 / 208

页数：6

共 18 条

[1] IRREVERSIBLE LYSOSOMAL DAMAGE INDUCED BY CHLOROQUINE IN RETINAE OF PIGMENTED AND ALBINO RATS [J].