CARDIOVASCULAR COLLAPSE FOLLOWING ORTHOCLONE OKT3 ADMINISTRATION - A CASE-REPORT

被引：15

作者：

LEE, CW

LOGAN, JL

ZUKOSKI, CF

机构：

[1] VET ADM MED CTR,RENAL TRANSPLANT SERV,TUCSON,AZ 85723

[2] UNIV ARIZONA,COLL MED,DEPT INTERNAL MED,TUCSON,AZ 85721

[3] UNIV ARIZONA,COLL MED,DEPT SURG,TUCSON,AZ 85721

来源：

AMERICAN JOURNAL OF KIDNEY DISEASES | 1991年 / 17卷 / 01期

关键词：

OKT3; ADVERSE EFFECTS; TRANSPLANTATION; KIDNEY;

D O I：

10.1016/S0272-6386(12)80254-X

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Orthoclone OKT3 has been described to have significant adverse effects on the cardiovascular system, including pulmonary edema, angina, dysrhythmias, hypertension, and hypotension, usually following the first or second doses of the drug. We describe a case of cardiopulmonary arrest in a patient 1 minute after the initial injection of OKT3. Two subsequent doses were successfully administered with the guidance of hemodynamic monitoring, which showed profound, immediate effects of OKT3 on the cardiovascular system. Potential mechanisms of these effects are discussed. © 1991, National Kidney Foundation, Inc.. All rights reserved.

引用

页码：73 / 75

页数：3

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