THE STRUCTURE OF THE HOMEODOMAIN AND ITS FUNCTIONAL IMPLICATIONS

被引：230

作者：

GEHRING, WJ ^{[1
]}

MULLER, M ^{[1
]}

AFFOLTER, M ^{[1
]}

PERCIVALSMITH, A ^{[1
]}

BILLETER, M ^{[1
]}

QIAN, YQ ^{[1
]}

OTTING, G ^{[1
]}

WUTHRICH, K ^{[1
]}

机构：

[1] SWISS FED INST TECHNOL,INST MOLEK BIOL & BIOPHYS,CH-8093 ZURICH,SWITZERLAND

来源：

TRENDS IN GENETICS | 1990年 / 6卷 / 10期

关键词：

D O I：

10.1016/0168-9525(90)90253-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The three-dimensional structure of the homeodomain, as determined by nuclear magnetic resonance spectroscopy, reveals the presence of a helix-turn-helix motif, similar to the one found in prokaryotic gene regulatory proteins. Isolated homeodomains bind with high affinity to specific DNA sequences. Thus, the structure-function relationship is highly conserved in evolution. © 1990.

引用

页码：323 / 329

页数：7

共 33 条

[1] Homeodomain proteins and the regulation of gene expression
Affolter, M.
Schier, A.
Gehring, W. J.
[J]. CURRENT OPINION IN CELL BIOLOGY, 1990, 2 (03) : 485 - 495
[2] DNA-BINDING PROPERTIES OF THE PURIFIED ANTENNAPEDIA HOMEODOMAIN
AFFOLTER, M
PERCIVALSMITH, A
MULLER, M
LEUPIN, W
GEHRING, WJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (11) : 4093 - 4097
[3] HOX AND HOM - HOMOLOGOUS GENE CLUSTERS IN INSECTS AND VERTEBRATES
AKAM, M
[J]. CELL, 1989, 57 (03) : 347 - 349
[4] AKAM M, 1987, DEVELOPMENT, V100, P1
[5] DETERMINATION OF THE 3-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM DROSOPHILA IN SOLUTION BY H-1 NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY
BILLETER, M
QIAN, Y
OTTING, G
MULLER, M
GEHRING, WJ
WUTHRICH, K
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1990, 214 (01) : 183 - 197
[6] COMPARISON OF THE HIGH-RESOLUTION STRUCTURES OF THE ALPHA-AMYLASE INHIBITOR TENDAMISTAT DETERMINED BY NUCLEAR MAGNETIC-RESONANCE IN SOLUTION AND BY X-RAY-DIFFRACTION IN SINGLE-CRYSTALS
BILLETER, M
KLINE, AD
BRAUN, W
HUBER, R
WUTHRICH, K
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1989, 206 (04) : 677 - 687
[7] BRENNAN RG, 1989, J BIOL CHEM, V264, P1903
[8] THE BICOID PROTEIN IS A POSITIVE REGULATOR OF HUNCHBACK TRANSCRIPTION IN THE EARLY DROSOPHILA EMBRYO
DRIEVER, W
NUSSLEINVOLHARD, C
[J]. NATURE, 1989, 337 (6203) : 138 - 143
[9] HOMEO BOXES IN THE STUDY OF DEVELOPMENT
GEHRING, WJ
[J]. SCIENCE, 1987, 236 (4806) : 1245 - 1252
[10] GIBSON G, IN PRESS CELL

← 1 2 3 4 →