POSSIBLE ROLE OF CA2+ IN HEAVY-METAL CYTOTOXICITY

被引:90
作者
VIARENGO, A [1 ]
NICOTERA, P [1 ]
机构
[1] KAROLINSKA INST,DEPT TOXICOL,S-10401 STOCKHOLM 60,SWEDEN
来源
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1991年 / 100卷 / 1-2期
关键词
D O I
10.1016/0742-8413(91)90127-F
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
1. Organic xenobiotic metabolism often results in oxidative stress, involving GSH depletion, alteration of thiol/disulphide balance and peroxidation of membrane lipids. These events can lead to the disruption of Ca2+ homeostasis, through impairment of the Ca2+ translocases present in cellular membranes. Inhibition of the activity of Ca, Mg-ATPases due to oxidation of their SH groups would lead to uncontrolled rises in cytosolic Ca2+ levels resulting in loss of cell viability. 2. These observations seem to be of interest when interpreting the biochemical mechanisms of heavy metal cytotoxicity. Since these cations (such as Hg2+, Cu2+, Cd2+ and Zn2+) have an extremely high affinity for SH groups, they may affect the function of SH containing proteins, such as the Ca,Mg-ATPases, as in the case of oxidative stress. 3. Results are reported indicating that Hg2+ may stimulate Ca2+ influx through voltage-dependent channels in different experimental systems. Moreover, evidence is presented that heavy metals can inhibit Ca,Mg-ATPase activity and affect mitochondrial functions in the cells of different organisms. 4. The possibility that heavy metal cytotoxicity is mediated through disruption of Ca2+ homeostasis is discussed.
引用
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页码:81 / 84
页数:4
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