FUNCTION OF THE HYPOTHALAMO-HYPOPHYSIAL-THYROID AXIS IN CHRONIC RENAL-FAILURE

被引：26

作者：

GOMEZPAN, A

ALVAREZUDE, F

YEO, PPB

HALL, R

EVERED, DC

KERR, DNS

机构：

[1] CIBA FDN,41 PORTLAND PL,LONDON W1N 4BN,ENGLAND

[2] CIUDAD SANIT PRIMERO OCTUBRE,SERV NEFROL,MADRID,SPAIN

[3] FAC MED MADRID,ESCUELA IBEROAMER ENDOCRINOL SEGURIDAD SOCIAL,MADRID 3,SPAIN

[4] UNIV SINGAPORE,DEPT MED,SINGAPORE,SINGAPORE

来源：

CLINICAL ENDOCRINOLOGY | 1979年 / 11卷 / 05期

关键词：

D O I：

10.1111/j.1365-2265.1979.tb03110.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hypothalamo‐hypophysial‐thyroid function has been studied in twenty‐five patients with chronic renal failure. Eight were receiving conservative treatment, nine peritoneal dialysis and eight haemodialysis. All were clinically euthyroid. Total thyroxine (T4) and triiodothyronine (T3) levels were reduced but free T4 levels were normal, while free T3 was reduced in patients with the most severe renal failure. It is suggested that the binding of thyroid hormones by the transport proteins is reduced and that peripheral conversion of T4 to T3 is impaired in renal failure. The thyrotrophin response to thyrotrophin‐releasing hormone (TRH) is reduced in renal failure but this reduction is probably independent of alterations in thyroid hormone metabolism. Growth hormone was released by TRH in seven of the patients studied, possibly as a result of protein malnutrition. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：567 / 574

页数：8

共 26 条

[1] SERUM GROWTH-HORMONE RESPONSES TO THYROTROPIN RELEASING HORMONE IN CHILDREN WITH PROTEIN-CALORIE MALNUTRITION
BECKER, D
KRONHEIM, S
PIMSTONE, B
[J]. HORMONE AND METABOLIC RESEARCH, 1975, 7 (04) : 358 - 359
[2] HIGH INCIDENCE OF DECREASED SERUM TRIIODOTHYRONINE CONCENTRATION IN PATIENTS WITH NON-THYROIDAL DISEASE
BERMUDEZ, F
SURKS, MI
OPPENHEIMER, JH
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1975, 41 (01) : 27 - 40
[3] BRANDT M, 1976, LANCET, V1, P491
[4] BURGER A, 1976, LANCET, V1, P653
[5] BURR WA, 1975, LANCET, V2, P1277
[6] RECIPROCAL CHANGES IN SERUM CONCENTRATIONS OF 3,3',5'-TRIIODOTHYRONINE (REVERSE T3) AND 3,3'5-TRIIODOTHYRONINE (T3) IN SYSTEMIC ILLNESSES
CHOPRA, IJ
CHOPRA, U
SMITH, SR
REZA, M
SOLOMON, DH
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1975, 41 (06) : 1043 - 1049
[7] ABNORMAL TSH, PRL AND GH RESPONSE TO TSH RELEASING FACTOR IN CHRONIC RENAL-FAILURE
CZERNICHOW, P
DAUZET, MC
BROYER, M
RAPPAPORT, R
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1976, 43 (03) : 630 - 637
[8] ASSESSMENT OF THYROID-HORMONE ASSAYS
EVERED, DC
VICE, PA
GREEN, E
APPLETON, D
[J]. JOURNAL OF CLINICAL PATHOLOGY, 1976, 29 (12) : 1054 - 1059
[9] HYPOTHALAMIC HORMONE INTERACTION IN ACROMEGALY
GOMEZPAN, A
TUNBRIDGE, WMG
DUNS, A
HALL, R
BESSER, GM
COY, DH
SCHALLY, AV
KASTIN, AJ
[J]. CLINICAL ENDOCRINOLOGY, 1975, 4 (05) : 455 - 460
[10] RESPONSES TO THYROTROPIN-RELEASING HORMONE IN PATIENTS WITH RENAL-FAILURE AND AFTER INFUSION IN NORMAL MEN
GONZALEZ.D
KASTIN, AJ
SCHALCH, DS
TORRESZA.M
PEREZPAS.E
KATO, A
SCHALLY, AV
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1973, 36 (01) : 117 - 120

← 1 2 3 →