ANALYSIS OF FCE-23762 (METHOXYMORPHOLINODOXORUBICIN HYDROCHLORIDE), A NEW ANTITUMOR AGENT, BY HPTLC AND SCANNING DENSITOMETRY

被引:4
作者
FARINA, A [1 ]
QUAGLIA, MG [1 ]
DOLDO, A [1 ]
CALANDRA, S [1 ]
GALLO, FR [1 ]
机构
[1] UNIV ROMA LA SAPIENZA,DIPARTIMENTO STUDI FARMACEUT,I-00185 ROME,ITALY
关键词
METHOXYMORPHOLINODOXORUBICIN HYDROCHLORIDE (FCE 23762); HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHY (HPTLC); DENSITOMETRY; PURITY CONTROL;
D O I
10.1016/0731-7085(93)80106-B
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A simple, rapid and reproducible high-performance thin-layer chromatographic (HPTLC) method using UV or fluorescence scanning densitometry has been developed for the assay and purity control of methoxymorpholinodoxorubicin hydrochloride (FCE 23762). With a mobile phase of chloroform-methanol-acetic acid (93:6:1, v/v/v) and a silica gel plate, all potential impurities were separated from the main component and from each other. Detection limits at a signal to-noise ratio of 2:1 were a few nanograms for UV detection and <1 ng for fluorescence emission. The RSD values for the examined compounds were all <3%.
引用
收藏
页码:1215 / 1218
页数:4
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