THE EPIDEMIOLOGY OF SUBACUTE SCLEROSING PANENCEPHALITIS IN ENGLAND AND WALES 1970-1989

被引:82
作者
MILLER, C
FARRINGTON, CP
HARBERT, K
机构
[1] PHLS Communicable Disease Surveillance Centre, London, NW9 5EQ
关键词
D O I
10.1093/ije/21.5.998
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Two hundred and ninety cases of subacute sclerosing panencephalitis (SSPE) registered in England and Wales from 1970 to 1989 were followed at 6-monthly intervals. Male to female ratio was 2.8:1. Age at onset increased significantly over the period. Measles was recorded for 81% of cases; in nearly half this had occurred under 2 years. Measles vaccine was documented in 20 cases; in 10 measles was also documented and it could not be positively excluded in the remainder. The calculated risk of SSPE following measles was 4.0/100000 cases compared with the risk after vaccine of 0. 14/100000 doses. Measles under 1 year carried a risk 16 times greater than measles over 5 years. There was an excess of cases in third and subsequent children. The incidence was higher in the northwest than in the southeast of the country. Survival time varied from 4 weeks to 16 years and was shorter when measles had occurred over the mean age of 2.5 years. Of the cases 9% had a history of mental retardation before the onset of SSPE. The incidence of SSPE has fallen following the reduction in measles resulting from vaccination. However, because of the median 8-year interval between measles and onset of SSPE, further cases arising from measles during the study period must still be expected, particularly in adolescents.
引用
收藏
页码:998 / 1006
页数:9
相关论文
共 50 条
[1]  
AABY P, 1984, REV INFECT DIS, V6, P239
[2]  
BELLMAN MH, 1980, BRIT MED J, V281, P393
[3]   REGISTER OF CASES OF SUBACUTE SCLEROSING PANENCEPHALITIS [J].
BELLMAN, MH ;
DICK, G .
BRITISH MEDICAL JOURNAL, 1977, 1 (6058) :430-431
[4]  
CALBIYE Y, 1988, J TROP PEDIATRICS, V34, P301
[5]  
CERNESCU C, 1988, Revue Roumaine de Medecine Virologie, V39, P247
[6]  
CONNOLLY JH, 1967, LANCET, V1, P542
[7]   MEASLES IMMUNOGLOBULINS IN SUBACUTE SCLEROSING PANENCEPHALITIS [J].
CONNOLLY, JH ;
HAIRE, M ;
HADDEN, DSM .
BRITISH MEDICAL JOURNAL, 1971, 1 (5739) :23-&
[8]  
Dawson JR, 1933, AM J PATHOL, V9, P7
[9]   SUBACUTE SCLEROSING PANENCEPHALITIS IN ONE MEMBER OF IDENTICAL-TWINS [J].
DHIBJALBUT, S ;
HADDAD, FS .
NEUROPEDIATRICS, 1984, 15 (01) :49-51
[10]  
DICK G, 1975, BRIT MED J, V3, P238