BONE-SCINTIGRAPHY IN OXALOSIS

被引:1
作者
MURTHY, S [1 ]
ROSEN, J [1 ]
CHAU, P [1 ]
ALTMAN, D [1 ]
ISRAEL, D [1 ]
机构
[1] MT SINAI MED CTR,DEPT CARDIOL,NEW YORK,NY 10029
关键词
D O I
10.1097/00003072-199308000-00016
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Several physiologic and pathologic conditions demonstrating extraosseous localization of bone scanning agents have been described, including metastatic calcification of the soft tissues secondary to metabolic disorders, malignancies, and chronic renal failure. However, extraosseous uptake in primary oxalosis has not been documented, although scintigraphic uptake pattern in a patient with primary oxalosis has been described. Oxalosis (Hyperoxaluria) is an autosomal recessive genetic disorder of glyoxylate metabolism. Type 1 (glycolic aciduria) is caused by the deficiency of 2-oxo-glutarate; glyoxylate carboligase results in excessive urinary excretion of oxalic, glycolic, and glyoxylic acids. Type-2 (L-glyceric aciduria) is caused by the deficiency of D-glyceric dehydrogenase and results in the accumulation of hydroxypyruvate and in excessive urinary excretion of oxalic and glyceric acids. Both are clinically indistinguishable and are characterized by formation of renal calculi and extrarenal deposits of calcium oxalate. Myocardium is a common site of oxalate deposits. Presented is a patient with primary oxalosis with renal and myocardial involvement visualized on bone scintigraphy.
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页码:704 / 705
页数:2
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