ISOLATION AND SYNTHESIS OF BENZ[A]ANTHRAQUINONES RELATED TO ANTITUMOR AGENT PD116740

被引：4

作者：

BRINKMAN, LC ^{[1
]}

LEY, FR ^{[1
]}

SEATON, PJ ^{[1
]}

机构：

[1] UNIV N CAROLINA,DEPT CHEM,WILMINGTON,NC 28403

来源：

JOURNAL OF NATURAL PRODUCTS | 1993年 / 56卷 / 03期

关键词：

D O I：

10.1021/np50093a009

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new benz[a]anthraquinones 1 and 2 and two known benz[a]anthraquinones 3 and 4 have been isolated as minor components from fermentations of actinomycete WP4669. Structural elucidation was based on standard spectroscopic analysis of compounds 1 and 2 and their acetates 5 and 6. Confirmation of structural assignments was achieved through synthesis of 1 and 2 from PD116740 [7]. Structural elucidation of minor products 8 and 9 and their acetates 10 and 11 produced from this synthetic route is also discussed.

引用

页码：374 / 380

页数：7

共 9 条

[1]

CARTER G, 1984, TETRAHEDRON LETT, P255

[2]

DANN M, 1965, ANTIMICROB AGENTS CH, P832

[3]

HALLEY K, 1991, J AM CHEM SOC, V113, P5092

[4] BIOSYNTHESIS OF VINEOMYCIN-A1 AND VINEOMYCIN-B2 [J].