GROUP SEQUENTIAL DESIGNS FOR ONE-SIDED AND 2-SIDED HYPOTHESIS-TESTING WITH PROVISION FOR EARLY STOPPING IN FAVOR OF THE NULL HYPOTHESIS

被引：135

作者：

PAMPALLONA, S ^{[1
]}

TSIATIS, AA ^{[1
]}

机构：

[1] HARVARD UNIV,SCH PUBL HLTH,DEPT BIOSTAT,BOSTON,MA 02115

来源：

JOURNAL OF STATISTICAL PLANNING AND INFERENCE | 1994年 / 42卷 / 1-2期

基金：

美国国家卫生研究院;

关键词：

GROUP SEQUENTIAL TESTS; REPEATED SIGNIFICANCE TEST; EARLY STOPPING IN FAVOR OF THE NULL HYPOTHESIS; STOPPING RULE; AVERAGE STOPPING TIME;

D O I：

10.1016/0378-3758(94)90187-2

中图分类号：

O21 [概率论与数理统计]; C8 [统计学];

学科分类号：

020208 ; 070103 ; 0714 ;

摘要：

In this paper we consider a class of boundaries for group sequential clinical trials that allow for early stopping also when small treatment differences are observed. They are based on the one-parameter family of boundaries introduced by Wang and Tsiatis (Biometrics 43 (1987) 193-199), can be derived exactly for any choice of type I and type II error probabilities, and can be easily applied to both one- and two-sided hypothesis testing. Plans corresponding to different choices of the design parameters are compared in terms of average sample number. Tables of relevant parameters are provided to help in the design of group sequential tests.

引用

页码：19 / 35

页数：17

共 17 条

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