INHIBITION OF ANGIOTENSIN-II-MEDIATED AND POTASSIUM-MEDIATED ALDOSTERONE SECRETION BY KN-62 SUGGESTS INVOLVEMENT OF CA2+-CALMODULIN DEPENDENT PROTEIN-KINASE-II IN ALDOSTERONE SECRETION

被引：9

作者：

GANGULY, A ^{[1
]}

LI, L ^{[1
]}

HAXTON, M ^{[1
]}

机构：

[1] JAMES A HALEY VET HOSP, TAMPA, FL 33612 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 209卷 / 03期

关键词：

D O I：

10.1006/bbrc.1995.1585

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Calcium is now acknowledged to play a major role as a cellular mediator of aldosterone secretion. However, the intricacies of the involvement of calcium in aldosterone secretion have not been clearly defined. We have shown here that calmodulin-dependent kinase II is involved in angiotensin II- and potassium-evoked aldosterone secretion as judged by the marked inhibitory effect of KN-62, a specific inhibitor of such a kinase, on aldosterone secretion and this inhibition was similar to that produced by calmodulin inhibitor, W-7. These results further strengthen the case for the participatory role of calcium-calmodulin system in aldosterone secretion. (C) Academic Press, Inc.

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收藏

页码：916 / 920

页数：5

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