A PHASE-II STUDY OF CARBOPLATIN AND VINORELBINE AS 2ND-LINE TREATMENT FOR ADVANCED BREAST-CANCER

被引：20

作者：

IAFFAIOLI, RV

TORTORIELLO, A

FACCHINI, G

SANTANGELO, M

DESENA, G

GESUE, G

BUCCI, L

SCARAMELLINO, G

ANASTASIO, E

FINIZIO, A

ANTONELLI, B

VALLEFUOCO, V

MOSELLA, G

CAPONIGRO, F

机构：

[1] UNIV CAGLIARI,IST MED INTERNA,I-09124 CAGLIARI,ITALY

[2] IST MED LEGALE AM,MILAN,ITALY

[3] OSPED AVELLINO,NAPLES,ITALY

[4] OSPED LORETO MARE,NAPLES,ITALY

[5] UNIV NAPLES FEDERICO II,NAPLES,ITALY

[6] OSPED VICO EQUENSE,NAPLES,ITALY

[7] OSPED INCURABILI,NAPLES,ITALY

[8] UNIV NAPLES FEDERICO II,NAPLES,ITALY

来源：

BRITISH JOURNAL OF CANCER | 1995年 / 72卷 / 05期

关键词：

ADVANCED BREAST CANCER; CARBOPLATIN; VINORELBINE; 2ND-LINE TREATMENT;

D O I：

10.1038/bjc.1995.496

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Forty-one patients with advanced breast cancer were given carboplatin and vinorelbine as second-line therapy. Overall objective response rate was 46% (95% confidence interval 26-56%). Myelotoxicity was the most frequently observed toxic effect; grade III-IV leucopenia occurred in 46% of the patients. Our regimen is active as second-line chemotherapy for advanced breast cancer and warrants further evaluation.

引用

页码：1256 / 1258

页数：3

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