NEW ASSAY OF 5-FLUOROURACIL IN SERUM BY ISOTACHOPHORESIS

被引：19

作者：

GUSTAVSSON, B ^{[1
]}

BALDESTEN, A ^{[1
]}

HASSELGREN, PO ^{[1
]}

ALMERSJO, O ^{[1
]}

机构：

[1] LKB PROD AB,S-16125 BROMMA,SWEDEN

来源：

JOURNAL OF CHROMATOGRAPHY | 1979年 / 179卷 / 01期

关键词：

D O I：

10.1016/S0021-9673(00)80666-4

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Blood levels of 5-fluorouracil are quantitatively determined by isotachophoresis. Serum is deproteinized, purified on an ion-exchange column and concentrated to 20 μl, and the drug is measured isotachophoretically. Down to 50 pmol (6.5 ng) of the drug can be determined in serum with a methodological error of ± 6%. The method can be used for routine control of patients undergoing therapy with the drug. © 1979.

引用

页码：151 / 159

页数：9

共 20 条

[1] CONCENTRATION OF BIOLOGICALLY-ACTIVE 5-FLUOROURACIL IN GENERAL CIRCULATION DURING CONTINUOUS PORTAL INFUSION IN MAN - PRELIMINARY-REPORT [J].