ACTIVITY OF CLARITHROMYCIN AND ITS PRINCIPAL HUMAN METABOLITE AGAINST HAEMOPHILUS-INFLUENZAE

被引:21
作者
JORGENSEN, JH
MAHER, LA
HOWELL, AW
机构
[1] Department of Pathology, University of Texas, Health Science Center, San Antonio
关键词
D O I
10.1128/AAC.35.7.1524
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Clarithromycin is a new macrolide antibiotic which forms a microbiologically active principal in vivo metabolite, 14-OH-clarithromycin. The in vitro activities of clarithromycin and its metabolite were examined separately and in pharmacokinetically relevant fixed combinations of 4:1 and 2:1 against a group of 50 Haemophilus influenzae isolates. Broth microdilution susceptibility tests indicated that clarithromycin was less active than erythromycin against all but highly erythromycin-susceptible strains, while 14-OH-clarithromycin was generally more active than either antibiotic. An enhancement in activity against the majority of strains was demonstrated when clarithromycin and its metabolite were tested in combination.
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页码:1524 / 1526
页数:3
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