CHYMOPAPAIN - A 10-YEAR, DOUBLE-BLIND-STUDY

被引：59

作者：

GOGAN, WJ ^{[1
]}

FRASER, RD ^{[1
]}

机构：

[1] ROYAL ADELAIDE HOSP,DEPT ORTHOPAED SURG & TRAUMA,ADELAIDE,SA 5000,AUSTRALIA

来源：

SPINE | 1992年 / 17卷 / 04期

关键词：

CHYMOPAPAIN; SCIATICA; DISK PROLAPSE;

D O I：

10.1097/00007632-199204000-00002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Sixty patients with sciatica from lumbar intervertebral disc herniation were entered into a double-blind study. Following a randomized schedule, 30 patients were treated with intradiscal chymopapain and 30 patients with intradiscal normal saline. At 10 years, with the patients still unaware of the treatment given, 80% of the chymopapain patients regarded the injection to be successful, compared with 34% for the saline group (P = 0.0006). Laminectomy was required in 20% of the chymopapain patients, compared with 47% of the saline patients (P = 0.028). Seventy-seven percent of the chymopapain group was assessed by a blinded independent observer to be at least moderately improved, compared with 38% for the saline group (P = 0.004). The results of this double-blind study at 10 years demonstrate a sustained therapeutic effect of chymopapain in the treatment of patients with sciatica from lumbar intervertebral disc prolapse.

引用

页码：388 / 394

页数：7

共 41 条

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