GLUCOCORTICOID RESISTANCE IN HUMANS

被引：10

作者：

MALCHOFF, CD ^{[1
]}

MALCHOFF, DM ^{[1
]}

机构：

[1] UNIV CONNECTICUT,CTR HLTH,SURG RES CTR,DEPT MED,FARMINGTON,CT 06030

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1995年 / 6卷 / 03期

关键词：

D O I：

10.1016/1043-2760(94)00213-N

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Generalized inherited glucocorticoid resistance is a rare disorder caused by glucocorticoid receptor mutations and characterized clinically by hypercortisolism. Pituitary and peripheral resistance are balanced so that neither adrenal insufficiency nor Cushingoid features develop. Clinical characteristics reflect overproduction of adrenal androgens and mineralocorticoids, which are caused by excess stimulation of the adrenal gland by ACTH. These clinical characteristics respond to dexamethasone therapy. Localized and/or acquired glucocorticoid resistance may occur in some circumstances.

引用

页码：89 / 95

页数：7

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