THE INTERFERON-INDUCIBLE GBP1 GENE - STRUCTURE AND MAPPING TO HUMAN-CHROMOSOME

被引：13

作者：

STREHLOW, I ^{[1
]}

LOHMANNMATTHES, ML ^{[1
]}

DECKER, T ^{[1
]}

机构：

[1] FRAUNHOFER INST TOXICOL & MOLEC BIOL,D-30625 HANNOVER,GERMANY

来源：

GENE | 1994年 / 144卷 / 02期

关键词：

GENOMIC CLONES; EXON; INTRON; GUANYLATE-BINDING PROTEIN; GENE EXPRESSION; GBP3;

D O I：

10.1016/0378-1119(94)90393-X

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have isolated DNA clones containing the interferon (IFN)-inducible guanylate-binding protein-1-encoding gene (GBP1) from a human genomic library. Two overlapping phage clones contained the entire GBP1 gene. The 2880 bp corresponding to the GBP1 cDNA were subdivided into eleven exons which were interrupted by a total of 9500 bp of intron DNA. All exon/intron junctions contained consensus splice donor and acceptor sequences. Using hybrid rodent cell lines containing human chromosomes, GBP1 was mapped to human chromosome 1. In addition to GBP1, we detected and partially characterized a novel gene, GBP3, with a structure related to GBP1 and a high degree of sequence homology to both GBP1 and GBP2. Our data suggest that the GBP family of genes contains members other than the previously characterized GBP1 and GBP2.

引用

页码：295 / 299

页数：5

共 16 条

[1]

BREATHNACH R, 1981, ANNU REV BIOCHEM, V50, P349, DOI 10.1146/annurev.bi.50.070181.002025

[2]

CHENG YSE, 1985, J BIOL CHEM, V260, P5834

[3] NONIDENTICAL INDUCTION OF THE GUANYLATE BINDING-PROTEIN AND THE 56K PROTEIN BY TYPE-I AND TYPE-II INTERFERONS [J].

CHENG, YSE ;

BECKERMANLEY, MF ;

NGUYEN, TD ;

DEGRADO, WF ;

JONAK, GJ .

JOURNAL OF INTERFERON RESEARCH, 1986, 6 (04) :417-427

[4] INTERFERON-INDUCED GUANYLATE-BINDING PROTEINS LACK AN N(T)KXD CONSENSUS MOTIF AND BIND GMP IN ADDITION TO GDP AND GTP [J].

CHENG, YSE ;

PATTERSON, CE ;

STAEHELI, P .

MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (09) :4717-4725

[5] INTERACTIONS OF ALPHA-INTERFERON AND GAMMA-INTERFERON IN THE TRANSCRIPTIONAL REGULATION OF THE GENE ENCODING A GUANYLATE-BINDING PROTEIN [J].

DECKER, T ;

LEW, DJ ;

CHENG, YSE ;

LEVY, DE ;

DARNELL, JE .

EMBO JOURNAL, 1989, 8 (07) :2009-2014

[6]

HORISBERGER M, 1991, J VIROL, V66, P4705

[7] OVERLAPPING ELEMENTS IN THE GUANYLATE-BINDING PROTEIN GENE PROMOTER MEDIATE TRANSCRIPTIONAL INDUCTION BY ALPHA AND GAMMA INTERFERONS [J].

LEW, DJ ;

DECKER, T ;

STREHLOW, I ;

DARNELL, JE .

MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (01) :182-191

[8] NUCLEOTIDE-SEQUENCE OF THE GENE FOR HUMAN TRANSITION PROTEIN-1 AND ITS CHROMOSOMAL LOCALIZATION ON CHROMOSOME-2 [J].

LUERSSEN, H ;

MATTEI, MG ;

SCHROTER, M ;

GRZESCHIK, KH ;

ADHAM, IM ;

ENGEL, W .

GENOMICS, 1990, 8 (02) :324-330

[9]

Maeyer-Guignard D, 1988, INTERFERONS OTHER RE

[10]

MELTON DA, 1984, NUCLEIC ACIDS RES, V12, P7035, DOI 10.1093/nar/12.18.7035

← 1 2 →