A QUINIDINE TRANSFORMATION PRODUCT ISOLATED FROM QUINIDINE INJECTION

被引：2

作者：

LEVINE, J

MAIENTHAL, M

机构：

[1] Division of Pharmaceutical Sciences, Food and Drug Administration, U S. Department of Health, Education, and Welfare, Washington, District of Columbia

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 06期

关键词：

Column chromatography—separation; Crystallographic properties—identity; Degradation product; quinidine—isolated; identified; IR spectrophotometry—identity; Quinidine gluconate injection—transformation product;

D O I：

10.1002/jps.2600580631

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A substance found in quinidine gluconate injection containing α‐thioglycerol as a stabilizer has been identified as α‐(6 – methoxy – 4 – quinolyl) – 5 – (5,6 – dihydroxy – 3 – thia – n‐hexyl)‐2‐quinuclidine methanol. It is a product of anti‐Markowni‐koff addition of thioglycerol to the vinyl group of quinidine. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：770 / +

页数：1

共 4 条

[1] Modified cinchona alkaloids Part VI Niquidine
Gibbs, EM
Henry, TA
[J]. JOURNAL OF THE CHEMICAL SOCIETY, 1939, : 240 - 246
[2] Syntheses in the cinchona series I The simpler cinchona alkaloids and their dihydro derivatives
Heidelberger, M
Jacobs, WA
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1919, 41 : 817 - 833
[3] LEVINE J, 1961, J ASSOC OFF AGR CHEM, V44, P291
[4] ADDITION OF THIOGLYCOLIC ACID TO ALPHA-ALKENES
SMITH, B
HERNESTAM, S
[J]. ACTA CHEMICA SCANDINAVICA, 1954, 8 (07): : 1111 - 1119

← 1 →