REVERSIBILITY OF DIGITOXIN, STROPHANTHIDIN AND STROPHANTHIDIN-3-BROMOACETATE ACTIVITY ON PAPILLARY MUSCLE AND A MICROSOMAL GUINEA PIG NA(+)-K(+)-ATPASE

被引：14

作者：

FRICKE, U

KLAUS, W

机构：

[1] Pharmakologisches Institut der Universität, Mainz

来源：

EXPERIENTIA | 1969年 / 25卷 / 07期

关键词：

D O I：

10.1007/BF01897558

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The reversibility of the inhibitory action of strophanthidin, strophanthidin-3-bromoacetate, and digitoxin on the Na+-K+-ATPase activity (microsomal fraction, guinea-pig brain) was compared with the rate of decline of their positive inotropic effects (papillary muscle, guinea-pig heart) after exposure to drug-free solution. The actions of strophanthidin and digitoxin were easily reduced on both systems. Strophanthidin-3-bromoacetate, however, was found to have an irreversible blocking effect on the transport ATPase, whereas its inotropic action could be rapidly abolished. © 1969 Birkhäuser-Verlag.

引用

页码：685 / &

共 14 条

[1]

DRANSFELD H, 1966, ARCH EXP PATHOL PH, V254, P225

[2]

FRICKE U, THESIS MAINZ

[3]

GLYNN IM, 1964, PHARMACOL REV, V16, P381

[4]

GREEFF K, 1967, ARCH INT PHARMACOD T, V166, P350

[5]