COMPOUNDS WITH BRIDGEHEAD NITROGEN .62. NMR-SPECTRA AND STEREOCHEMISTRY OF PERHYDROPYRIDO[1,2-C][1,3]THIAZEPINES AND RELATED SYSTEMS

被引：2

作者：

CRABB, TA

FALLAH, A

机构：

[1] Department of Chemistry, Portsmouth Polytechnic, Portsmouth, Hampshire

来源：

MAGNETIC RESONANCE IN CHEMISTRY | 1990年 / 28卷 / 05期

关键词：

!sup]1[!/sup]H and [!sup]13[!/sup]C NMR; Perhydropyrido[1,2‐c][1,3]thiazepines;

D O I：

10.1002/mrc.1260280509

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Perhydropyrido[1,2‐c][1,3] thiazepine adopts (CDCl3 solution, 25°C) an equilibrium containing > 98% trans‐fused conformer, in contrast to perhydropyrido[1,2‐c][1,3]oxazepine, which adopts a ca. 74% trans‐fused ⇌ 26% O‐inside‐cis‐fused conformational equilibrium. The cis‐(H‐5a, H‐8)‐8‐ethyl‐substituted derivatives of both systems show increased preference for the S/O inside cis conformations. The related 2‐tert‐butylperhydropyrido[1,2‐c][1,3]diazepine adopts predominantly the trans‐fused conformation. Copyright © 1990 John Wiley & Sons, Ltd.

引用

页码：426 / 430

页数：5

共 8 条

[1]

BANTING L, 1990, J CHEM RES-S, P20

[2] COMPOUNDS WITH BRIDGEHEAD NITROGEN .51. THE NMR-SPECTRA AND STEREOCHEMISTRY OF THE 6-ETHYLINDOLIZIDINES [J].