THE HUMAN PROGENITOR-CELL ANTIGEN (CD34) IS LOCALIZED ON ENDOTHELIAL-CELLS, DERMAL DENDRITIC CELLS, AND PERIFOLLICULAR CELLS IN FORMALIN-FIXED NORMAL SKIN, AND ON PROLIFERATING ENDOTHELIAL-CELLS AND STROMAL SPINDLE-SHAPED CELLS IN KAPOSI-SARCOMA

被引:350
作者
NICKOLOFF, BJ
机构
关键词
D O I
10.1001/archderm.127.4.523
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
The human progenitor cell antigen (CD34) is selectively expressed on hematopoietic progenitor cells in the bone marrow. In either cryostat sections of snap-frozen skin, or formalin-fixed paraffin-embedded sections of normal skin, anti-CD34 monoclonal antibody immunostained vascular endothelial cells and perivascular/interstitial dendritic cells, particularly in the reticular dermis. A distinctive population of perifollicular spindle-shaped cells in the midportion of the follicle (ie, bulge area), which is the site of the putative hair follicle stem cells, were CD34 positive, as were spindle-shaped cells in and around the eccrine glands accentuating their basement membrane zone. In patch/plaque- and tumor-stage acquired immunodeficiency syndrome-associated Kaposi's sarcoma lesions, CD34 expression was present on both the proliferating endothelial cells as well as the spindle-shaped stromal cells. CD34 positive endothelial cells and spindle-shaped stromal cells may play important participatory and supportive functions in both normal and diseased skin.
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页码:523 / 529
页数:7
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