ANTIBACTERIAL PROPERTIES OF THE BICYCLIC PYRAZOLIDINONES

被引：35

作者：

ALLEN, NE

HOBBS, JN

PRESTON, DA

TURNER, JR

WU, CYE

机构：

[1] Lilly Research Laboratories, Eli Lilly and Company, Indianapolis

来源：

JOURNAL OF ANTIBIOTICS | 1990年 / 43卷 / 01期

关键词：

D O I：

10.7164/antibiotics.43.92

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

LY173013 and LY186826 are bicyclic pyrazolidinones containing a novel aza-γ-lactam ring structure. The antibacterial properties of these compounds appear to be related to those of β-lactam antibiotics in that both classes of compounds share certain common binding molecules such as β-lactamases and penicillin-binding proteins. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

引用

收藏

页码：92 / 99

页数：8

相关论文

共 19 条

[1] INHIBITION OF PEPTIDOGLYCAN BIOSYNTHESIS IN GRAM-POSITIVE BACTERIA BY LY146032 [J].

ALLEN, NE ;

HOBBS, JN ;

ALBORN, WE .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1987, 31 (07) :1093-1099

[2] MOLECULAR MODELING OF GAMMA-LACTAM ANALOGS OF BETA-LACTAM ANTIBACTERIAL AGENTS - SYNTHESIS AND BIOLOGICAL EVALUATION OF SELECTED PENEM AND CARBAPENEM ANALOGS [J].

ALLEN, NE ;

BOYD, DB ;

CAMPBELL, JB ;

DEETER, JB ;

ELZEY, TK ;

FOSTER, BJ ;

HATFIELD, LD ;

HOBBS, JN ;

HORNBACK, WJ ;

HUNDEN, DC ;

JONES, ND ;

KINNICK, MD ;

MORIN, JM ;

MUNROE, JE ;

SWARTZENDRUBER, JK ;

VOGT, DG .

TETRAHEDRON, 1989, 45 (07) :1905-1928

[3] 1,3-DIPOLAR CYCLOADDITION REACTIONS OF PYRAZOLIDINIUM YLIDES WITH ACETYLENES - SYNTHESIS OF A NEW CLASS OF ANTIBACTERIAL AGENTS [J].

JUNGHEIM, LN ;

SIGMUND, SK .

JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (18) :4007-4013

[4] BICYCLIC PYRAZOLIDINONES, A NEW CLASS OF ANTIBACTERIAL AGENT BASED ON THE BETA-LACTAM MODEL [J].

JUNGHEIM, LN ;

SIGMUND, SK ;

FISHER, JW .

TETRAHEDRON LETTERS, 1987, 28 (03) :285-288

[5] BICYCLIC PYRAZOLIDINONES, STERIC AND ELECTRONIC EFFECTS ON ANTIBACTERIAL ACTIVITY [J].

JUNGHEIM, LN ;

SIGMUND, SK ;

JONES, ND ;

SWARTZENDRUBER, JK .

TETRAHEDRON LETTERS, 1987, 28 (03) :289-292

[6]

LUGTENBERG EJJ, 1971, J MICROBIOL SEROL, V37, P537

[7] SUBSTRATE INHIBITION OF BETA-LACTAMASES, A METHOD FOR PREDICTING ENZYMATIC STABILITY OF CEPHALOSPORINS [J].

MAHONEY, DF ;

KOPPEL, GA ;

TURNER, JR .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1976, 10 (03) :470-475

[8] REGULATION OF MUREIN BIOSYNTHESIS AND SEPTUM FORMATION IN FILAMENTOUS CELLS OF ESCHERICHIA-COLI PAT-84 [J].

MIRELMAN, D ;

YASHOUVGAN, Y ;

SCHWARZ, U .

JOURNAL OF BACTERIOLOGY, 1977, 129 (03) :1593-1600

[9] BIOSYNTHESIS OF PEPTIDOGLYCAN IN PSEUDOMONAS-AERUGINOSA .1. INCORPORATION OF PEPTIDOGLYCAN INTO THE CELL-WALL [J].

MIRELMAN, D ;

NUCHAMOWITZ, Y .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1979, 94 (02) :541-548

[10] PEPTIDOGLYCAN BIOSYNTHESIS IN A THERMOSENSITIVE DIVISION MUTANT OF ESCHERICHIA-COLI [J].

MIRELMAN, D ;

YASHOUVGAN, Y ;

SCHWARZ, U .

BIOCHEMISTRY, 1976, 15 (09) :1781-1790