MICROSURGICAL FERTILIZATION AND TERATOZOOSPERMIA

被引：50

作者：

COHEN, J

TALANSKY, BE

MALTER, H

ALIKANI, M

ADLER, A

REING, A

BERKELEY, A

GRAF, M

DAVIS, O

LIU, H

BEDFORD, JM

ROSENWAKS, Z

机构：

[1] Center for Reproductive Medicine and Infertility, Department of Obstetrics and Gynecology, New York Hospital, Cornell University Medical Center, NY

来源：

HUMAN REPRODUCTION | 1991年 / 6卷 / 01期

关键词：

PARTIAL ZONA PELLUCIDA DISSECTION; SUBZONAL SPERM INSERTION; POLYSPERMY; IMPLANTATION;

D O I：

10.1093/oxfordjournals.humrep.a137244

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Semen parameters were correlated with the outcome of partial zona dissection (PZD) in 42 couples with male factor infertility. Although fertilization rates were reduced, 12% of the embryos implanted following replacement. Spermatozoa from teratozoospermic sperm populations were able to fuse with oocytes following zona penetration through the artificial gaps. PZD followed by insemination with < 5% normal spermatozoa led to 20 embryos which, upon replacement, did not implant. Motility and sperm count were not clearly correlated with the outcome of PZD and are therefore less useful indicators for patient selection. Teratozoospermic patients who previously failed to fertilize were compared to a group of similar patients who had not attempted IVF before. Although fertilization was significantly improved in first-time patients, 41% of the patients whose spermatozoa were initially unable to fertilize had at least one embryo when PZD was performed. Several pregnancies were established in this group. Subzonal sperm insertion (SZI) and PZD were compared in 19 patients using sibling oocytes. A significant fraction of spermatozoa from infertile men were able to fuse with the oolemma when directly inserted into the perivitelline area. Using a sucrose solution to shrink the ooplasm, only 1% of the oocytes were damaged during SZI. Monospermic fertilization rates following PZD and SZI were 15 and 16%, respectively. Both micromanipulation methods were successful in most patients. However, in two small groups of patients, only one technique resulted in fertilization.

引用

页码：118 / 123

页数：6

共 22 条

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