THE MOLECULAR-GENETICS OF FAMILIAL VENOUS THROMBOSIS

被引：18

作者：

COOPER, DN

机构：

[1] Molecular Genetics Section, Thrombosis Research Institute, London, SW3 6LR, Manresa Road, Chelsea

来源：

BLOOD REVIEWS | 1991年 / 5卷 / 01期

关键词：

D O I：

10.1016/0268-960X(91)90009-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Inherited defects of antithrombin III, protein C, protein S, heparin cofactor II, plasminogen and the fibrinogens are thought to be responsible for between 10 and 15% of all patients presenting with recurrent venous thrombosis. The structure, function and expression of these genes and the nature of the gene lesions underlying the deficiency states are reviewed in detail.

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页码：55 / 70

页数：16

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