BUPRENORPHINE ALONE AND IN COMBINATION WITH NALOXONE IN NONDEPENDENT HUMANS

被引：51

作者：

WEINHOLD, LL ^{[1
]}

PRESTON, KL ^{[1
]}

FARRE, M ^{[1
]}

LIEBSON, IA ^{[1
]}

BIGELOW, GE ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,BEHAV PHARMACOL RES UNIT,BALTIMORE,MD 21205

来源：

DRUG AND ALCOHOL DEPENDENCE | 1992年 / 30卷 / 03期

关键词：

BUPRENORPHINE; NALOXONE; OPIOID; ABUSE LIABILITY; HUMAN;

D O I：

10.1016/0376-8716(92)90061-G

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

This study evaluated the effects of concurrent naloxone on the opioid agonist effects of buprenorphine, a mixed agonist-antagonist marketed as an analgesic and under development as a treatment for drug abuse. In a residential laboratory seven non-physically-dependent opioid abuser volunteers received intramuscular buprenorphine (0.4 mg or 0.8 mg/70 kg) alone and in combination with naloxone (0.4 mg or 0.8 mg/70 kg) versus placebo. Buprenorphine produced dose-related opioid agonist effects on physiological and subjective measures. Concurrent naloxone attenuated the opioid agonist effects of buprenorphine. Thus, a combination product of buprenorphine and naloxone may have lower abuse liability than buprenorphine alone.

引用

页码：263 / 274

页数：12

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