ANXIOLYTIC-LIKE EFFECT OF THE GABA-TRANSAMINASE INHIBITOR VIGABATRIN (GAMMA-VINYL GABA) ON RAT EXPLORATORY ACTIVITY

被引：42

作者：

SHERIF, F

HARRO, J

ELHWUEGI, A

ORELAND, L

机构：

[1] UPPSALA UNIV,CTR BIOMED,DEPT MED PHARMACOL,S-75124 UPPSALA,SWEDEN

[2] TARTU STATE UNIV,DEPT PHARMACOL,TARTU 202400,ESTONIA

[3] UNIV MED SCI,DEPT PHARMACOL & BIOCHEM,TRIPOLI,LIBYA

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1994年 / 49卷 / 04期

关键词：

GAMMA-VINYL GABA; VIGABATRIN; GABA-TRANSAMINASE; ELEVATED PLUS-MAZE; OPEN FIELD; EXPLORATORY ACTIVITY; ANXIETY;

D O I：

10.1016/0091-3057(94)90226-7

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Vigabatrin (gamma-vinyl GABA, GVG) is an irreversible inhibitor of GABA-transaminase (GABA-T). This study addressed the question of whether or not the inhibition of GABA-T has an anxiolytic effect in rats. Diazepam (1.5 mg/kg) and GvG (50 and 500 mg/kg) increased the tendency of rats to explore in the elevated plus-maze test, whereas the effect of general locomotor activity was diminished. The sedative effect of GVG (500 mg/kg) was more pronounced 6 h than 2 h after IP administration. The present findings suggest that even a partial inhibition of GABA-T results in a reduction of anxiety measures in a novel environment.

引用

页码：801 / 805

页数：5

共 26 条

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