A NOVEL GLYCOPROTEIN IN THE OLFACTORY AND PITUITARY SYSTEMS OF LARVAL AND ADULT LAMPREYS

被引：26

作者：

SOWER, SA

TAKAHASHI, A

NOZAKI, M

GORBMAN, A

YOUSON, JH

JOSS, J

KAWAUCHI, H

机构：

[1] KITASATO UNIV, SCH FISHERIES SCI, MOLEC ENDOCRINOL LAB, SANRIKU, IWATE 02201, JAPAN

[2] KYOTO UNIV, PRIMATE RES INST, INUYAMA, AICHI 484, JAPAN

[3] UNIV WASHINGTON, DEPT ZOOL, SEATTLE, WA 98195 USA

[4] UNIV TORONTO, DEPT ZOOL, TORONTO, ON M1C 1A4, CANADA

[5] MACQUARIE UNIV, SCH BIOL SCI, SYDNEY, NSW 2109, AUSTRALIA

来源：

ENDOCRINOLOGY | 1995年 / 136卷 / 01期

关键词：

D O I：

10.1210/en.136.1.349

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A novel homodimeric glycoprotein was isolated and characterized from the pituitaries of adult sea lampreys, Petromyzon marinus, modern representatives of the earliest vertebrates. The monomer consists of 121 amino-acid residues in a sequence that has no resemblance to any known pituitary hormone. Whereas this protein is localized in most cells of the rostral pars distalis of adult lampreys, we have chosen to name it, nasohypophysial factor (NHF), because it first appears in the olfactory system of developing larval lampreys. Not only may NHF be a new pituitary hormone but a useful probe for examining the ontogenetic and phylogenetic relationships of the pituitary and olfactory systems in vertebrates.

引用

页码：349 / 356

页数：8

共 34 条

[1] A STUDY OF CORTICOTROPIC AND MELANOTROPHIC ACTIVITIES IN THE PITUITARY AND BRAIN OF THE LAMPREY LAMPETRA-FLUVIATILIS [J].