COSEGREGATION OF BLOOD-PRESSURE WITH ANGIOTENSIN CONVERTING ENZYME AND ATRIAL-NATRIURETIC-PEPTIDE RECEPTOR GENES USING DAHL SALT-SENSITIVE RATS

被引：164

作者：

DENG, YL

RAPP, JP

机构：

[1] MED COLL OHIO, DEPT MED, TOLEDO, OH 43699 USA

[2] MED COLL OHIO, DEPT PATHOL, TOLEDO, OH 43699 USA

来源：

NATURE GENETICS | 1992年 / 1卷 / 04期

关键词：

D O I：

10.1038/ng0792-267

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have evaluated the genes for angiotensin converting enzyme (ACE) and guanylyl cyclase A/atrial natriuretic peptide receptor (GCA) for genetic effects on blood pressure response to high salt diet. In F2 rats derived from Milan normotensive and Dahl salt-hypertension sensitive (S) rats, both ACE and GCA cosegregated with blood pressure, and rats that were homozygous for the S allele at both the ACE and GCA loci had inordinately high blood pressure. In F2 derived from Wistar Kyoto (WKY) and S rats, GCA revealed positive cosegregation with blood pressure, but ACE did not. We conclude that certain alleles at the GCA and ACE loci (or at loci closely linked to them) have a significant genetic impact on blood pressure response to high salt in specific rat strains.

引用

页码：267 / 272

页数：6

共 34 条

[1] RENIN AND ATRIAL-NATRIURETIC-PEPTIDE RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISMS - ASSOCIATION WITH ETHNICITY AND BLOOD-PRESSURE
BARLEY, J
CARTER, ND
CRUICKSHANK, JK
JEFFERY, S
SMITH, A
CHARLETT, A
WEBB, DJ
[J]. JOURNAL OF HYPERTENSION, 1991, 9 (11) : 993 - 996
[2] Bianchi G., 1984, HDB HYPERTENSION, V4, P328
[3] GENERAL METHOD FOR ISOLATION OF HIGH MOLECULAR-WEIGHT DNA FROM EUKARYOTES
BLIN, N
STAFFORD, DW
[J]. NUCLEIC ACIDS RESEARCH, 1976, 3 (09) : 2303 - 2308
[4] TAIL-CUFF BLOOD-PRESSURE MEASUREMENT WITHOUT EXTERNAL PREHEATING IN AWAKE RATS
BUNAG, RD
BUTTERFIELD, J
[J]. HYPERTENSION, 1982, 4 (06) : 898 - 903
[5] EFFECTS OF CHRONIC EXCESS SALT INGESTION - EVIDENCE THAT GENETIC FACTORS PLAY AN IMPORTANT ROLE IN SUSCEPTIBILITY TO EXPERIMENTAL HYPERTENSION
DAHL, LK
HEINE, M
TASSINARI, L
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1962, 115 (06) : 1173 - &
[6] FRIEDMAN M, 1949, P SOC EXP BIOL MED, V70, P670
[7] CHROMOSOMAL MAPPING OF 2 GENETIC-LOCI ASSOCIATED WITH BLOOD-PRESSURE REGULATION IN HEREDITARY HYPERTENSIVE RATS
HILBERT, P
LINDPAINTNER, K
BECKMANN, JS
SERIKAWA, T
SOUBRIER, F
DUBAY, C
CARTWRIGHT, P
DEGOUYON, B
JULIER, C
TAKAHASI, S
VINCENT, M
GANTEN, D
GEORGES, M
LATHROP, GM
[J]. NATURE, 1991, 353 (6344) : 521 - 529
[8] DAHL S-RATS HAVE INCREASED NATRIURETIC FACTOR IN ATRIA BUT ARE MARKEDLY HYPORESPONSIVE TO IT
HIRATA, Y
GANGULI, M
TOBIAN, L
IWAI, J
[J]. HYPERTENSION, 1984, 6 (02) : I148 - I155
[9] TRANSCRIPTION OF TESTICULAR ANGIOTENSIN-CONVERTING ENZYME (ACE) IS INITIATED WITHIN THE 12TH INTRON OF THE SOMATIC ACE GENE
HOWARD, TE
SHAI, SY
LANGFORD, KG
MARTIN, BM
BERNSTEIN, KE
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (08) : 4294 - 4302
[10] GENETIC-MAPPING OF A GENE CAUSING HYPERTENSION IN THE STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RAT
JACOB, HJ
LINDPAINTNER, K
LINCOLN, SE
KUSUMI, K
BUNKER, RK
MAO, YP
GANTEN, D
DZAU, VJ
LANDER, ES
[J]. CELL, 1991, 67 (01) : 213 - 224

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