PROTON RELAXATION ENHANCEMENT BY MEANS OF SERUM-ALBUMIN AND POLY-L-LYSINE LABELED WITH DTPA-GD3+ - RELAXIVITIES AS A FUNCTION OF MOLECULAR-WEIGHT AND CONJUGATION EFFICIENCY

被引：62

作者：

SPANOGHE, M

LANENS, D

DOMMISSE, R

VANDERLINDEN, A

ALDERWEIRELDT, F

机构：

[1] Department of Organic Chemistry, University of Antwerp (RUCA), Antwerp

[2] Research Group for Biomedical NMR University of Antwerp (UIA), Antwerp

来源：

MAGNETIC RESONANCE IMAGING | 1992年 / 10卷 / 06期

关键词：

MAGNETIC RESONANCE IMAGING; (DTPA-GD)-LABELING; MACROMOLECULAR CONTRAST AGENTS;

D O I：

10.1016/0730-725X(92)90445-6

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A series of poly-L-lysine chains, with molecular weight ranging from 3300 up to 102,000 Da, were labeled with DTPA-Gd3+. No significant differences in longitudinal and transversal relaxivity, could be demonstrated as a function of the chain length. The R1 and R2 relaxivities were respectively 2.5 and 5 times superior to those of plain DTPA-Gd3+ (at 2.4 T). Bovine serum albumin was also labeled in a way that a wide (DTPA-Gd3+)/BSA range (3-39) was obtained. The longitudinal relaxivity, of these paramagnetically labeled albumins, increased with increasing (DTPA-Gd3+)/BSA ratios. This effect was most pronounced at very low (DTPA-Gd3+)/BSA ratios.

引用

页码：913 / 917

页数：5

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