INTERACTIONS BETWEEN DOPAMINE AND EXCITATORY AMINO-ACIDS IN BEHAVIORAL SENSITIZATION TO PSYCHOSTIMULANTS

被引:163
作者
KALIVAS, PW
机构
[1] Alcohol and Drug Abuse Program, Washington State University, Pullman, WA
关键词
DOPAMINE; GLUTAMATE; VENTRAL TEGMENTAL AREA; NUCLEUS ACCUMBENS; PREFRONTAL CORTEX; SENSITIZATION; COCAINE;
D O I
10.1016/0376-8716(94)01063-Q
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Mesoaccumbens dopamine transmission at least partly mediates the initiation and expression of behavioral sensitization to psychostimulants. The initiation arises from an action by psychostimulants on dopamine cell bodies in the ventral tegmental area (VTA) while the expression of behavioral sensitization involves enhanced pre- and postsynaptic dopamine transmission in the nucleus accumbens. Evidence is emerging that excitatory amino acid (EAA) transmission is also involved in behavioral sensitization to psychostimulants. In this report, evidence is presented that the initiation of behavioral sensitization involves stimulation of NMDA receptors in the VTA which may occur via enhanced presynaptic release of EAAs following activation of D-1 receptors. It is further posited that EAA transmission in the nucleus accumbens may promote the expression of sensitization by increasing presynaptic dopamine release and modulating the postsynaptic actions of dopamine.
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页码:95 / 100
页数:6
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