Association study of dopamine D3 receptor gene and schizophrenia

被引:54
作者
Kennedy, JL
Billett, EA
Macciardi, FM
Verga, M
Parsons, TJ
Meltzer, HY
Lieberman, J
Buchanan, JA
机构
[1] CASE WESTERN RESERVE UNIV,SCH MED,CLEVELAND,OH
[2] HILLSIDE HOSP,GLEN OAKS,NY 11004
[3] UNIV TORONTO,N YORK GEN HOSP,MOLEC GENET LAB,TORONTO,ON,CANADA
来源
AMERICAN JOURNAL OF MEDICAL GENETICS | 1995年 / 60卷 / 06期
关键词
DNA polymorphism molecular genetics; schizophrenia; DRD3;
D O I
10.1002/ajmg.1320600615
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Several groups have reported an association between schizophrenia and the MscI polymorphism in the first exon of the dopamine D3 receptor gene (DRD3). We studied this polymorphism using a North American sample (117 patients plus 188 controls) and an Italian sample (97 patients plus 64 controls). In the first part of the study, we compared allele frequencies of schizophrenia patients and unmatched controls and observed a significant difference in the total sample (P = 0.01). The second part of the study involved a case control approach in which each schizophrenia patient was matched to a control of the same sex, and of similar age and ethnic background. The DRD3 allele frequencies of patients and controls revealed no significant difference between the two groups in the Italian (N = 53) or the North American (N = 54) matched populations; however, when these two matched samples were combined, a significant difference was observed (P = 0.026). Our results suggest that the MscI polymorphism may be associated with schizophrenia in the populations studied. (C) 1995 Wiley-Liss, Inc.
引用
收藏
页码:558 / 562
页数:5
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