EFFECT OF KAINIC ACID-INDUCED STATUS EPILEPTICUS ON INOSITOL-TRISPHOSPHATE AND SEIZURE-INDUCED BRAIN-DAMAGE IN MATURE AND IMMATURE ANIMALS

被引：18

作者：

CARMANT, L ^{[1
]}

LIU, Z ^{[1
]}

WERNER, SJ ^{[1
]}

MIKATI, MA ^{[1
]}

HOLMES, GL ^{[1
]}

机构：

[1] HARVARD UNIV, CHILDRENS HOSP, SCH MED, DEPT NEUROL, BOSTON, MA 02115 USA

来源：

DEVELOPMENTAL BRAIN RESEARCH | 1995年 / 89卷 / 01期

关键词：

KAINIC ACID; STATUS EPILEPTICUS; INOSITOL-TRISPHOSPHATE; SEIZURE-INDUCED BRAIN DAMAGE; EXCITATORY AMINO ACID;

D O I：

10.1016/0165-3806(95)00110-Y

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We investigated the role of excitatory amino acids in the activation of the phosphoinositide pathway during kainic acid-induced seizures in mature and immature animals. Kainic acid caused more severe seizures in the immature animals, but no hippocampal damage or induction of phosphoinositide hydrolysis. In mature animals, seizures were mild but severe hippocampal damage was seen and was associated with a marked and sustained release of inositol-trisphosphate, suggesting a role of this pathway and intracellular calcium stores in seizure-induced brain damage.

引用

页码：67 / 72

页数：6

共 57 条

[1] KAINIC-ACID-INDUCED SEIZURES - A DEVELOPMENTAL-STUDY [J].

ALBALA, BJ ;

MOSHE, SL ;

OKADA, R .

DEVELOPMENTAL BRAIN RESEARCH, 1984, 13 (01) :139-148

[2] SYNAPTIC ACTIVATION OF METABOTROPIC GLUTAMATE RECEPTORS IN THE PARALLEL FIBER-PURKINJE CELL PATHWAY IN RAT CEREBELLAR SLICES [J].

BATCHELOR, AM ;

MADGE, DJ ;

GARTHWAITE, J .

NEUROSCIENCE, 1994, 63 (04) :911-915

[3] MATURATION OF KAINIC ACID SEIZURE BRAIN DAMAGE SYNDROME IN THE RAT .3. POSTNATAL-DEVELOPMENT OF KAINIC ACID BINDING-SITES IN THE LIMBIC SYSTEM [J].

BERGER, ML ;

TREMBLAY, E ;

NITECKA, L ;

BENARI, Y .

NEUROSCIENCE, 1984, 13 (04) :1095-1104

[4] DEVELOPMENTAL-CHANGES IN INTRACELLULAR CALCIUM REGULATION IN RAT CEREBRAL-CORTEX DURING HYPOXIA [J].

BICKLER, PE ;

GALLEGO, SM ;

HANSEN, BM .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1993, 13 (05) :811-819

[5]

BODJARIAN N, 1993, NEUROREPORT, V4, P1191

[6] ONTOGENETIC DEVELOPMENT OF KAINATE NEUROTOXICITY - CORRELATES WITH GLUTAMATERGIC INNERVATION [J].

CAMPOCHIARO, P ;

COYLE, JT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (04) :2025-2029

[7] THE SUSCEPTIBILITY OF RATS TO PILOCARPINE-INDUCED SEIZURES IS AGE-DEPENDENT [J].

CAVALHEIRO, EA ;

SILVA, DF ;

TURSKI, WA ;

CALDERAZZOFILHO, LS ;

BORTOLOTTO, ZA ;

TURSKI, L .

DEVELOPMENTAL BRAIN RESEARCH, 1987, 37 (1-2) :43-58

[8] GLUTAMATE METABOTROPIC RECEPTORS INCREASE A CA2+-ACTIVATED NONSPECIFIC CATIONIC CURRENT IN CA1 HIPPOCAMPAL-NEURONS [J].

CREPEL, V ;

ANIKSZTEJN, L ;

BENARI, Y ;

HAMMOND, C .

JOURNAL OF NEUROPHYSIOLOGY, 1994, 72 (04) :1561-1569

[9] IMMATURE RABBIT HIPPOCAMPUS IS DAMAGED BY SYSTEMIC BUT NOT INTRAVENTRICULAR KAINIC ACID [J].

FRANCK, JE ;

SCHWARTZKROIN, PA .

DEVELOPMENTAL BRAIN RESEARCH, 1984, 13 (02) :219-227

[10]

GLAUM SR, 1992, J NEUROSCI, V12, P2251

← 1 2 3 4 5 6 →