BYSTANDER DAMAGE OF HOST MUSCLE CAUSED BY IMPLANTATION OF MHC-COMPATIBLE MYOGENIC CELLS

被引：30

作者：

WERNIG, A

IRINTCHEV, A

机构：

[1] Department of Physiology, Neurophysiology, University of Bonn, D-53111 Bonn

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1995年 / 130卷 / 02期

关键词：

MYOBLAST TRANSPLANTATION; MUSCLE DYSTROPHY; HISTOCOMPATIBILITY; IMMUNE REJECTION; T LYMPHOCYTES; MUSCLE REGENERATION; MUSCLE DAMAGE;

D O I：

10.1016/0022-510X(95)00034-Y

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Transplantation of normal myoblasts has been considered a potential therapy for muscle dystrophies. While survival of implanted cells has been described in animal experiments and in human trials, functional effects remained unclear. Here we report on survival of progenors of implanted C2nlsBAG cells in regenerating muscles but irreversible net loss in muscle tissue and contractile force. This is caused by immune rejection of implanted myoblasts despite MHC-compatibility and ''bystander'' damage of host muscle tissue.

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收藏

页码：190 / 196

页数：7

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