BIOAVAILABILITY OF CONVENTIONAL AND SLOW-RELEASE OXPRENOLOL IN FASTED AND NON-FASTED INDIVIDUALS

1 The influence of food and plasma levels of oxprenolol was examined in healthy female volunteers using both conventional and slow‐release formulations. 2 There were no significant trends in plasma drug profiles due to food with either formulation. Elimination half‐lives were longer after food with conventional tablets, presumably due to continued absorption. The opposite effect was seen with slow‐release tablets. 3 Slow‐release oxprenolol is, under the conditions of this study, a reliable and convenient dosage form, providing similar plasma‐ drug profiles in fasted and nonfasted individuals. 1979 The British Pharmacological Society