IMPROVEMENT OF THE INVITRO DISSOLUTION CHARACTERISTICS OF FAMOTIDINE BY INCLUSION IN BETA-CYCLODEXTRIN

An inclusion complex between famotidine and β-cyclodextrin was prepared by mixing the two components in a millimolar ratio in distilled water and heating under reflux for l h followed by stirring at room temperature for 5 days. Phase-solubility studies revealed the formation of a 1:1 complex of the AL type with a rate constant of 74.96 M-1. The formation of the complex in the solid state was confirmed by infrared spectroscopy and differential scanning calorimetry. The inclusion complex was shown by X-ray powder diffraction to be significantly less crystalline than any of the pure components. More significantly, the dissolution rate of the complex from constant surface-area discs was determined to be about twice and six times higher than that of the physical mixture and the pure drug, respectively. © 1990.