CONTROL ANALYSIS OF SYSTEMS HAVING 2 STEPS CATALYZED BY THE SAME PROTEIN MOLECULE IN UNBRANCHED CHAINS

被引：10

作者：

CASCANTE, M ^{[1
]}

CANELA, EI ^{[1
]}

FRANCO, R ^{[1
]}

机构：

[1] UNIV BARCELONA, FAC QUIM,SCH CHEM,DEPT BIOQUIM & FISIOL, UNITAT BIOQUIM & BIOL MOLEC, DIAGONAL 647, E-08028 BARCELONA, SPAIN

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 1990年 / 192卷 / 02期

关键词：

D O I：

10.1111/j.1432-1033.1990.tb19236.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The analysis of the control of a metabolic pathway having an enzyme catalyzing two different reactions (or a protein displaying two different activities) has been performed. For such systems although the summation theorems are valid, the flux and concentration connectivity theorems of the metabolic control analysis are not valid. Another general relationship of control analysis is shown to be more widely obeyed and holds in these systems. An exemplary case, where the enzyme catalyzes two irreversible reactions, demonstrates that the level of one internal intermediate is constant, i.e. it does not depend upon the independent variables of the system. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：369 / 371

页数：3

共 16 条

[1]

BECKER MA, 1987, J BIOL CHEM, V262, P14531

[2] USE OF IMPLICIT METHODS FROM GENERAL SENSITIVITY THEORY TO DEVELOP A SYSTEMATIC-APPROACH TO METABOLIC CONTROL .1. UNBRANCHED PATHWAYS [J].