NEUROFIBRILLARY TANGLES OF THE INDIANA KINDRED OF GERSTMANN-STRAUSSLER-SCHEINKER DISEASE SHARE ANTIGENIC DETERMINANTS WITH THOSE OF ALZHEIMER-DISEASE

被引：59

作者：

GIACCONE, G

TAGLIAVINI, F

VERGA, L

FRANGIONE, B

FARLOW, MR

BUGIANI, O

GHETTI, B

机构：

[1] INDIANA UNIV,SCH MED,DEPT PATHOL,DIV NEUROPATHOL,635 BARNHILL DR,INDIANAPOLIS,IN 46202

[2] IST NEUROCHIRURG C BESTA,DIV NEUROPATHOL,I-20133 MILAN,ITALY

[3] NYU MED CTR,DEPT PATHOL,NEW YORK,NY 10016

来源：

BRAIN RESEARCH | 1990年 / 530卷 / 02期

关键词：

Alz50; Alzheimer disease; Amyloid plaque; Gerstmann-Sträussler-Scheinker disease; Immunohistochemistry; Neuritic plaque; Neurofibrillary tangle; Neuropil thread; Paired helical filament; Ubiquitin;

D O I：

10.1016/0006-8993(90)91304-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the Indiana kindred of Gerstmann-Sträussler-Scheinker disease, neurofibrillary tangles (NFT) with paired helical filaments (PHF) are numerous, widespread and consistently present in the cerebral cortex and several subcortical nuclei. Such tangles share antigenic determinants with those of Alzheimer disease; in fact, they are recognized by Alz50, anti-PHF and anti-ubiquitin antibodies. Thus, NFT with structural and immunocytochemical similarities are present in two distinct forms of amyloidosis of the central nervous system, i.e. the Indiana kindred of Gerstmann-Sträussler-Scheinker disease and Alzheimer disease. © 1990.

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页码：325 / 329

页数：5

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