EFFECT OF NIFEDIPINE ON CYCLOSPORINE A-INDUCED NEPHROTOXICITY, URINARY ENDOTHELIN EXCRETION AND RENAL ENDOTHELIN RECEPTOR NUMBER

被引：40

作者：

BROOKS, DP ^{[1
]}

OHLSTEIN, EH ^{[1
]}

CONTINO, LC ^{[1
]}

STORER, B ^{[1
]}

PULLEN, M ^{[1
]}

CALTABIANO, M ^{[1
]}

NAMBI, P ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,DEPT CELL SCI,KING OF PRUSSIA,PA 19406

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 194卷 / 01期

关键词：

CYCLOSPORINE; ENDOTHELIN; NEPHROTOXICITY; CA-2+ CHANNEL ANTAGONISTS; NIFEDIPINE;

D O I：

10.1016/0014-2999(91)90132-A

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of the present study was to determine the effect of a calcium channel blocker on renal function, urinary endothelin excretion and endothelin receptor number in rats. Administration of cyclosporine resulted in a significant impairment of renal function when measured by either [C-14]inulin or 24 h creatinine clearances. This nephrotoxicity was associated with statistically significant (P < 0.05) increases in urinary endothelin excretion and renal endothelin receptor number. Treatment with nifedipine attenuated cyclosporine A-induced renal dysfunction and reduced urinary endothelin excretion. The data provide further evidence of a role for endothelin in cyclosporine A-induced nephrotoxicity.

引用

页码：115 / 117

页数：3

共 12 条

[1]

BROOKS DP, 1990, J PHARMACOL EXP THER, V254, P375

[2] CARDIOVASCULAR AND RENAL ACTIONS OF ENDOTHELIN - EFFECTS OF CALCIUM-CHANNEL BLOCKERS [J].

CAO, LQ ;

BANKS, RO .

AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 258 (02) :F254-F258

[3]

DADAN J, 1990, KIDNEY INT, V37, P479

[4] ANTAGONIST CAPACITIES OF NIFEDIPINE, CAPTOPRIL, PHENOXYBENZAMINE, PROSTACYCLIN AND INDOMETHACIN ON CYCLOSPORINE-A INDUCED IMPAIRMENT OF RAT RENAL-FUNCTION [J].

DIEPERINK, H ;

LEYSSAC, PP ;

STARKLINT, H ;

JORGENSEN, KA ;

KEMP, E .

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 1986, 16 (06) :540-548

[5] REGIONAL HEMODYNAMIC-EFFECTS OF ENDOTHELIN-1 AND ENDOTHELIN-3 IN CONSCIOUS LONG EVANS AND BRATTLEBORO RATS [J].

GARDINER, SM ;

COMPTON, AM ;

BENNETT, T .

BRITISH JOURNAL OF PHARMACOLOGY, 1990, 99 (01) :107-112

[6] CARDIOVASCULAR, RENAL, AND ENDOCRINE RESPONSES TO INTRAVENOUS ENDOTHELIN IN CONSCIOUS DOGS [J].

GOETZ, KL ;

WANG, BC ;

MADWED, JB ;

ZHU, JL ;

LEADLEY, RJ .

AMERICAN JOURNAL OF PHYSIOLOGY, 1988, 255 (06) :R1064-R1068

[7] ENDOTHELIN - A POTENT RENAL AND SYSTEMIC VASOCONSTRICTOR PEPTIDE [J].

KING, AJ ;

BRENNER, BM ;

ANDERSON, S .

AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 256 (06) :F1051-F1058

[8] ROLE OF ENDOTHELIN IN CYCLOSPORINE-INDUCED GLOMERULAR DYSFUNCTION [J].

KON, V ;

SUGIURA, M ;

INAGAMI, T ;

HARVIE, BR ;

ICHIKAWA, I ;

HOOVER, RL .

KIDNEY INTERNATIONAL, 1990, 37 (06) :1487-1491

[9] SYNTHESIS OF THE VASOCONSTRICTOR PEPTIDE ENDOTHELIN IN KIDNEY-CELLS [J].

KOSAKA, T ;

SUZUKI, N ;

MATSUMOTO, H ;

ITOH, Y ;

YASUHARA, T ;

ONDA, H ;

FUJINO, M .

FEBS LETTERS, 1989, 249 (01) :42-46

[10] UP-REGULATION OF RENAL ENDOTHELIN RECEPTORS IN RATS WITH CYCLOSPORINE A-INDUCED NEPHROTOXICITY [J].

NAMBI, P ;

PULLEN, M ;

CONTINO, LC ;

BROOKS, DP .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 187 (01) :113-116

← 1 2 →