SITES OF PROTONATION IN CARDIOTONIC POLYAZAINDOLIZINES BY NMR-SPECTROSCOPY

被引：17

作者：

BARRACLOUGH, P

FIRMIN, D

LINDON, JC

NOBBS, MS

SANDERSON, PN

SMITH, S

GILLAM, JM

机构：

[1] WELLCOME RES LABS,DEPT PHYS SCI,LANGLEY COURT,BECKENHAM BR3 3BS,KENT,ENGLAND

[2] WELLCOME RES LABS,DEPT MED CHEM,BECKENHAM BR3 3BS,KENT,ENGLAND

来源：

MAGNETIC RESONANCE IN CHEMISTRY | 1991年 / 29卷 / 05期

关键词：

POLYAZAINDOLIZINES; PROTONATION; C-13; NMR; H-1 NMR PK VALUES;

D O I：

10.1002/mrc.1260290511

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The pK(a) values of six sulmazole analogues were measured spectrophotometrically. The major protonation sites for most of these bridgehead nitrogen heterocycles were determined by H-1 and C-13 NMR methods. The aryl-substituted imidazo[1,2-a]pyrimidine (4), 8-methoxyimidazo[1,2-a]pyrazine (6), imidazo[1,2-b]pyridazine (9) and imidazo[1,2-b][1,2,4]triazine (11) undergo protonation at the imidazo nitrogen. The imidazo[1,2-a]pyrazine (5) protonates mainly at N-7. In some cases difference in basicity properties between these aryl analogues and the bridgehead heterocycles have been observed.

引用

页码：468 / 475

页数：8

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