PATHOLOGICAL AND LABORATORY FINDINGS IN LEC OTK RATS THAT SPONTANEOUSLY DEVELOP HEPATIC-INJURY

被引:8
作者
KAWANO, K
HIRASHIMA, T
MORI, S
BANDO, S
YONEMOTO, K
ABE, F
GOTO, H
NATORI, T
机构
[1] Tokushima Research Institute, Otsuka Pharmaceutical Co. Ltd, Tokushima
关键词
HEREDITARY; MICROVESICULAR FATTY CHANGES; PATHOLOGY; RAT; SPONTANEOUS HEPATIC INJURY;
D O I
10.1111/j.1440-1746.1991.tb00875.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The LEC strain of rats that spontaneously develops hepatic injury has been introduced into specific pathogen-free (SPF) conditions (SPF-LEC/Otk). The present communication describes the clinical and pathological features of the SPF-LEC/Otk rats. The characteristic features of these animals are as follows: (i) Jaundice develops in almost all rats with increase in the P-GPT level; (ii) The animals show episodes of jaundice, a high P-GPT level and liver cell necrosis, but only slight inflammatory cell infiltration; (iii) The liver cells show characteristic microvesicular fatty changes; (iv) The P-GPT level shows increases, first at 18 weeks and then at 25 weeks of age; (v) The rats show immunological disorders, such as deficiency of immunoglobulins, especially IgG1, and of helper T cells; (vi) Infectious agents such as viruses do not seem to be involved, although this possibility cannot be absolutely excluded; (vii) The immunological disorders are not directly associated with the occurrence of liver cell necrosis; and (viii) The pattern of inheritance (autosomal single-recessive trait) of the disease strongly suggests that it is due to a genetic metabolic disorder.
引用
收藏
页码:377 / 382
页数:6
相关论文
共 9 条
[1]  
DAWLING HF, 1964, JAMA-J AM MED ASSOC, V188, P307
[2]  
DEMPO K, 1988, J TOXICOL PATHOL, V1, P53
[3]   ACCUMULATION OF ABNORMALLY HIGH PLOID NUCLEI IN THE LIVER OF LEC RATS DEVELOPING SPONTANEOUS HEPATITIS [J].
FUJIMOTO, Y ;
OYAMADA, M ;
HATTORI, A ;
TAKAHASHI, H ;
SAWAKI, M ;
DEMPO, K ;
MORI, M ;
NAGAO, M .
JAPANESE JOURNAL OF CANCER RESEARCH, 1989, 80 (01) :45-50
[4]   FATTY LIVER OF PREGNANCY AND ITS RELATIONSHIP TO TETRACYCLINE THERAPY [J].
KUNELIS, CT ;
PETERS, JL ;
EDMONDSON, HA .
AMERICAN JOURNAL OF MEDICINE, 1965, 38 (03) :359-+
[5]   HEREDITARY HEPATITIS OF LEC RATS IS CONTROLLED BY A SINGLE AUTOSOMAL RECESSIVE GENE [J].
MASUDA, R ;
YOSHIDA, MC ;
SASAKI, M ;
DEMPO, K ;
MORI, M .
LABORATORY ANIMALS, 1988, 22 (02) :166-169
[6]  
SASAKI M, 1985, RAT NEWS LETT, V14, P4
[7]   METABOLIC PREDISPOSITION OF A NOVEL MUTANT (LEC RATS) TO HEREDITARY HEPATITIS AND HEPATOMA - ALTERATIONS OF THE DRUG-METABOLIZING ENZYMES [J].
SUGIYAMA, T ;
TAKEICHI, N ;
KOBAYASHI, H ;
YOSHIDA, MC ;
SASAKI, M ;
TANIGUCHI, N .
CARCINOGENESIS, 1988, 9 (09) :1569-1572
[8]  
TAKEICHI N, 1988, ACTA PATHOL JAPON, V38, P1369
[9]   NEW MUTATION CAUSING HEREDITARY HEPATITIS IN THE LABORATORY RAT [J].
YOSHIDA, MC ;
MASUDA, R ;
SASAKI, M ;
TAKEICHI, N ;
KOBAYASHI, H ;
DEMPO, K ;
MORI, M .
JOURNAL OF HEREDITY, 1987, 78 (06) :361-365