CHROMATIN STRUCTURE, DNA METHYLATION, AND GENE-EXPRESSION AT SITES OF VIRAL INTEGRATION IN HUMAN FIBROBLASTS - IMPLICATIONS FOR CHROMOSOMAL FRAGILITY

被引：10

作者：

DEAMBROSIS, A ^{[1
]}

CASCIANO, I ^{[1
]}

QUERZOLA, F ^{[1
]}

VIDALI, G ^{[1
]}

ROMANI, M ^{[1
]}

机构：

[1] INST SCI TUMORI,IST NAZL RICERCA CANCRO,MOLEC BIOL LAB,VIALE BENEDETTO XV 10,I-16132 GENOA,ITALY

来源：

CANCER GENETICS AND CYTOGENETICS | 1992年 / 60卷 / 01期

关键词：

D O I：

10.1016/0165-4608(92)90223-U

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We analyzed the structural and functional properties of a chromosomal region in which a recombinant hybrid virus adenovirus 5/SV40 preferentially integrates. Our results demonstrated that the structure of the cellular targets for DNA and RNA viruses is very similar and that the cellular sequence flanking the integrated virus possesses, simultaneously, all the features postulated to be the molecular basis for chromosomal fragility.

引用

页码：1 / 7

页数：7

共 37 条

[1]

BIRD A, 1985, CELL, V40, P91, DOI 10.1016/0092-8674(85)90312-5

[2] CPG-RICH ISLANDS AND THE FUNCTION OF DNA METHYLATION [J].

BIRD, AP .

NATURE, 1986, 321 (6067) :209-213

[3] REPORT OF THE COMMITTEE ON STRUCTURAL CHROMOSOME CHANGES IN NEOPLASIA [J].

BLOOMFIELD, CD ;

TRENT, JM ;

VANDENBERGHE, H .

CYTOGENETICS AND CELL GENETICS, 1987, 46 (1-4) :344-366

[4] RETROVIRUS-INDUCED LETHAL MUTATION IN COLLAGEN-I GENE OF MICE IS ASSOCIATED WITH AN ALTERED CHROMATIN STRUCTURE [J].

BREINDL, M ;

HARBERS, K ;

JAENISCH, R .

CELL, 1984, 38 (01) :9-16

[5] CORRECT INTEGRATION OF RETROVIRAL DNA INVITRO [J].

BROWN, PO ;

BOWERMAN, B ;

VARMUS, HE ;

BISHOP, JM .

CELL, 1987, 49 (03) :347-356

[6] TEMPORAL-ORDER OF CHROMATIN STRUCTURAL-CHANGES ASSOCIATED WITH ACTIVATION OF THE MAJOR CHICKEN VITELLOGENIN GENE [J].

BURCH, JBE ;

WEINTRAUB, H .

CELL, 1983, 33 (01) :65-76

[7] REGIONAL CHROMOSOME LOCALIZATION OF HUMAN PAPILLOMAVIRUS INTEGRATION SITES NEAR FRAGILE SITES, ONCOGENES, AND CANCER CHROMOSOME BREAKPOINTS [J].

CANNIZZARO, LA ;

DURST, M ;

MENDEZ, MJ ;

HECHT, BK ;

HECHT, F .

CANCER GENETICS AND CYTOGENETICS, 1988, 33 (01) :93-98

[8]

DOERFLER W, 1983, CURR TOP MICROBIOL, V109, P193

[9] EXCISION OF AMPLIFIED VIRAL-DNA AT PALINDROMIC SEQUENCES FROM THE ADENOVIRUS TYPE-12-TRANSFORMED HAMSTER-CELL LINE T637 [J].

EICK, D ;

KEMPER, B ;

DOERFLER, W .

EMBO JOURNAL, 1983, 2 (11) :1981-1986

[10] SIMIAN VIRUS-40 EARLY-REGION AND LATE-REGION PROMOTER FUNCTIONS ARE ENHANCED BY THE 72-BASE-PAIR REPEAT INSERTED AT DISTANT LOCATIONS AND INVERTED ORIENTATIONS [J].

FROMM, M ;

BERG, P .

MOLECULAR AND CELLULAR BIOLOGY, 1983, 3 (06) :991-999

← 1 2 3 4 →